The net effect of the sex-specific antagonism of Gro-mediated repression is that the two-fold difference in XSE dose is converted into a robust all-or-nothing response at SxlPe. Bibcode : NatCo Thus, the female-specific mRNA lacks the termination codon.
Notch signaling is used reiteratively during development in numerous cell-fate specification events. The rapid clearance of SXL protein from the cytoplasm of the dividing cysts is also important for oocyte differentiation.
These structural variants, which are evolutionarily conserved, encode slightly different proteins. Bibcode : NatCo It appears that high values of the X:A ratio are responsible for activating the feminizing switch gene Sex-lethal Sxl.
Male and female genitalia in Drosophila are derived from separate cell populations. References 1. Together, these observations suggest that in addition to its RNA binding activity SXL requires protein-protein interactions to achieve selective and specific binding to its target RNAs.
Horabin JI, Schedl P.
Expression of the period clock gene within different cell types in the brain of Drospohila adults and mosaic analysis of these cells' influence on circadian behavioral rhythms. This refers to the rhythm of the locomotor activity of a fly during its h activity cycle.
Gerlai, R. Hinman MN, Lou H. Genetics—
Another protein recently identified as part of the machinery required for skipping the male exon is Protein Partner of Sansfille PPS , the Drosophila protein most closely related to the yeast histone H3K4me3 binding protein BYE1. Alvarado, Dennis A. PLoS Biol.
Sxl activity orchestrates sex-specific development and behavior by modulating the expression of a set of downstream genes. For example, this technique showed that male courtship behavior is controlled by the brain. For example the mammalian Hu proteins resemble SXL in that they have diverse molecular functions ranging from splicing to translational regulation.